منابع مشابه
Acid–base regulation of bone metabolism
It has been known for almost a century that systemic acidosis causes depletion of the skeleton—an effect assumed to result from physicochemical dissolution of bone mineral. However, our work has shown that resorption pit formation by cultured osteoclasts is dependent on extracellular acidification. Osteoclasts are almost inactive above pH 7.4 and show maximum acidactivation at about pH 6.9. Wit...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1923
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)85468-0